Water → HCID 59305034、化合物

HRID 2240253ノート

反応式

HRID 2240253 の反応式
[OH-].[Na+].[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[N:6](S(C2C=CC(C)=CC=2)(=O)=O)[CH:5]=1.O.C(OCC)(=O)C>C(O)C>[F:3][C:4]1[C:12]2[C:11]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=3[F:23])=[CH:10][CH:9]=[N:8][C:7]=2[NH:6][CH:5]=1

参加物

6

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 59304991HCID 59304991、化合物

生成物 1

HCID 59305034HCID 59305034、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.4 ml of a 20% strength aqueous sodium hydroxide solution is added to a solution of 80 mg (0.18 mmol) of 3-fluoro-N-(2-fluoro-4-nitrophenyl)-1-[(4-methylphenyl)-sulfonyl]-1H-pyrrolo[2,3-b]pyridine-4-amine in 5 ml of ethanol, and the mixture is stirred overnight. The reaction solution is then poured into a mixture of water and ethyl acetate, and the aqueous phase is extracted two more times with ethyl acetate. Purification by preparative HPLC gives the target compound.

後処理

  1. extractionthe aqueous phase is extracted two more times with ethyl acetate
  2. customPurification by preparative HPLC
  3. customgives the target compound

出典と根拠

ORDレコード
ord-74da6de7d8484f7ab9e285fae406a443
出典データセット
uspto-grants-2010_05
特許番号
US07723347B2

反応ノート

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