2,4,6-Trimethylaniline → 4-Amino-3,5-dimethylbenzaldehyde
反応式
[CH3:1][C:2]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH3:10])[C:3]=1[NH2:4].[O:11]1CCOCC1>>[NH2:4][C:3]1[C:5]([CH3:10])=[CH:6][C:7]([CH:9]=[O:11])=[CH:8][C:2]=1[CH3:1]参加物
3
実験手順
To a solution of 2,4,6-trimethylaniline (29.8 g, 0.22 mol) in dioxane (300 mL) DDQ (49.9 g, 0.22 mol) is added. The brown suspension is stirred at rt for 18 h before it is filtered. The solvent of the filtrate is evaporated and the crude product is purified by CC on silica gel eluting with hexane:EA 1:1 to give 4-amino-3,5-dimethyl-benzaldehyde (5.0 g) as a beige solid; LC-MS: tR=0.78 min, [M+1]+=150.26.
後処理
- filtrationis filtered
- customThe solvent of the filtrate is evaporated
- customthe crude product is purified by CC on silica gel eluting with hexane:EA 1:1
出典と根拠
- ORDレコード
- ord-b7d2397462eb4d65b510356d00e7b9a3
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07723378B2
反応ノート
読み込み中…