Ethanol → HCID 16112965、化合物

HRID 2240926ノート

反応式

HRID 2240926 の反応式
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15](O)C=2)=O)=[CH:6][CH:5]=1.Cl.[CH3:23][NH:24][C:25]([NH2:27])=[NH:26].[C:28](=[O:31])([O-])[O-].[Na+].[Na+].C([OH:36])C>>[NH2:26][C:25]1[N:24]([CH3:23])[C:28](=[O:31])[C:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:1])[F:21])=[CH:9][CH:8]=2)([C:11]2[CH:13]=[CH:18][CH:17]=[C:16]([OH:36])[CH:15]=2)[N:27]=1

参加物

5

反応物 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 59790334HCID 59790334、化合物HCID 178485118HCID 178485118、化合物

生成物 1

HCID 16112965HCID 16112965、化合物収率 64%

反応条件

温度
85 °C

実験手順

1-(4-(difluoromethoxy)phenyl)-2-(3-hydroxyphenyl)ethane-1,2-dione (0.11 g, 0.38 mmol) was dissolved in ethanol (5 mL). Methylguanidine hydrochloride (0.052 g, 0.47 mmol) was added followed by sodium carbonate (0.050 g, 0.47 mmol). The mixture was stirred at 85° C. overnight 15 hours. The solvent was removed and the material is absorbed onto celite. Purification by flash chromatography afforded 2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-hydroxyphenyl)-1-methyl-1H-imidazol-5(4H)-one (0.085 g, 64%).

後処理

  1. customThe solvent was removed
  2. customthe material is absorbed onto celite
  3. customPurification by flash chromatography

出典と根拠

ORDレコード
ord-b977d5e6c5ba49fbbd2421b3273dbf91
出典データセット
uspto-grants-2010_05
特許番号
US07723368B2

反応ノート

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