Diethyl Ether → 5-Ethynyl-2-fluorophenol

HRID 2240929ノート

反応式

HRID 2240929 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C(C)C)(C(C)C)C(C)C)=[CH:4][C:3]=1[OH:20].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CCOCC>C1COCC1>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([OH:20])[CH:4]=1)#[CH:9]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 2724141Tetrabutylammonium FluorideHCID 593053612-Fluoro-5-((triisopropylsilyl)ethynyl)phenol

生成物 1

HCID 593053355-Ethynyl-2-fluorophenol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2-fluoro-5-((triisopropylsilyl)ethynyl)phenol is dissolved in THF and tetrabutyl ammoniumflouride is added. The solution is stirred overnight at RT. Et2O is added and the solution is washed with H2O, Brine, dried, and the solvent removed. This material is used without any further purification.

後処理

  1. washthe solution is washed with H2O, Brine
  2. customdried
  3. customthe solvent removed
  4. customThis material is used without any further purification

出典と根拠

ORDレコード
ord-aaa542c5d2664447b8f74091e6b99878
出典データセット
uspto-grants-2010_05
特許番号
US07723368B2

反応ノート

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