p-Toluenesulfonic acid → 9-Hydroxy-3-(2-hydroxyethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

HRID 2241081ノート

反応式

HRID 2241081 の反応式
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:9]([CH:12]1[CH2:17][CH2:16][O:15][C:13]1=[O:14])(=O)[CH3:10].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C(C)=CC=CC=1>[OH:8][C:7]1[C:2]2=[N:1][C:9]([CH3:10])=[C:12]([CH2:17][CH2:16][OH:15])[C:13](=[O:14])[N:3]2[CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 106012-AcetylbutyrolactoneHCID 281142-Amino-3-Hydroxypyridine

生成物 1

HCID 166560309-Hydroxy-3-(2-hydroxyethyl)-2-methylpyrido[1,2-a]pyrimidin-4-one

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

During chemical development this process was altered. 2-Amino-3-hydroxypyridine was reacted with 2-acetyl-butyrolactone in the presence of p-toluenesulfonic acid in xylene to yield 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; this product proved to be poorly soluble in xylene resulting in deposit formation on the wall of the reaction vessel and discoloration of the reaction mixture to black.

出典と根拠

ORDレコード
ord-ca54f693271e48ac9014840f257d2981
出典データセット
uspto-grants-2010_05
特許番号
US07723518B2

反応ノート

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