4-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine → 4-Morpholino-3-(trifluoromethyl)aniline

HRID 2241911ノート

反応式

HRID 2241911 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[C:6]([C:16]([F:19])([F:18])[F:17])[CH:5]=1)([O-])=O>[Pt](=O)=O.CO>[O:13]1[CH2:12][CH2:11][N:10]([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][C:6]=2[C:16]([F:18])([F:19])[F:17])[CH2:15][CH2:14]1

参加物

4

反応物 1

HCID 6128564-(4-Nitro-2-(trifluoromethyl)phenyl)morpholine

生成物 1

HCID 27713294-Morpholino-3-(trifluoromethyl)aniline収率 58%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

A mixture of 4-[4-nitro-2-(trifluoromethyl)phenyl]morpholine (compound of Reference Example 2; 1.20 g, 4.344 mmol), platinum(IV) oxide (0.10 g) and methanol (12 ml) was stirred at room temperature for 12.5 hours under hydrogen atmosphere. The reaction mixture was filtered and the residue obtained by evaporation of the solvent of the filtrate under reduced pressure was washed with n-hexane to give the title compound (0.62 g, 58%) as a colorless crystal.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe residue obtained by evaporation of the solvent of the filtrate under reduced pressure
  3. washwas washed with n-hexane

出典と根拠

ORDレコード
ord-94bc5a01980a45948f8fcd0f231bdc88
出典データセット
uspto-grants-2010_03
特許番号
US07671058B2

反応ノート

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