Methyl isobutyrate → HCID 21181993、化合物

HRID 22421

反応式

HRID 22421 の反応式
[CH:1](NC1CCCCC1)(C)C.[Li]CCCC.[C:16]([O:21][CH3:22])(=[O:20])[CH:17]([CH3:19])[CH3:18].IC[CH2:25][CH2:26][CH2:27][O:28][CH3:29]>C1COCC1.CN(P(N(C)C)(N(C)C)=O)C>[CH3:18][C:17]([CH3:1])([CH2:19][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[C:16]([O:21][CH3:22])=[O:20]

参加物

7

反応物 4

HCID 11039Methyl isobutyrateHCID 62386CyclohexylisopropylamineHCID 227078941-Iodo-4-methoxybutaneHCID 178418339Butyllithium

生成物 1

HCID 21181993HCID 21181993、化合物収率 85%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒2 回HCID 12679Hexamethylphosphoramide溶媒

反応条件

温度
-78 °C

実験手順

To N-isopropylcyclohexylamine (5.96 ml) in THF (30 ml) was added dropwise n-BuLi (1,6-M, 22.7 ml) at -78° C., and the mixture was stirred for 30 min, to which a THF (5 ml) solution of methyl isobutyrate (3.43 g) was added, and stirred at -78° C. for 45 min. Then, a HMPA (6.3 ml) solution of 1-iodo-4-methoxy-butane (9.05 g) was added to the mixture, and stirred at room temperature for 1 h to give methyl 2,2-dimethyl-6-methoxycaproate (4.81 g, 85%) after usual work-up.

後処理

  1. additionwas added
  2. stirringstirred at room temperature for 1 h

出典と根拠

ORDレコード
ord-e5728deaed1d48c68392a710194dac45
出典データセット
uspto-grants-1995_06
特許番号
US05428062

関連ノート

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