Phenylsulphonyl isocyanate → HCID 23332186、化合物

HRID 224215

反応式

HRID 224215 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([N:8]([CH3:10])[CH3:9])[CH:5]=[C:4]([CH3:11])[N:3]=1.[C:12]1([S:18]([N:21]=[C:22]=[O:23])(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)Cl.CC(C)=O>[CH3:9][N:8]([CH3:10])[C:6]1[CH:5]=[C:4]([CH3:11])[N:3]=[C:2]([NH:1][C:22]([NH:21][S:18]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)(=[O:20])=[O:19])=[O:23])[N:7]=1

参加物

5

反応物 2

HCID 76096Phenylsulphonyl isocyanateHCID 137293006,N4,N4-trimethyl-pyrimidine-2,4-diamine

生成物 1

HCID 23332186HCID 23332186、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 15.2 g of 2-amino-4-dimethylamino-6-methylpyrimidine in 400 ml of methylene chloride at ambient temperature was added slowly 18.3 g of benzenesulfonylisocyanate. After stirring for four hours the mixture was stripped in-vacuo and the white semisolid residue triturated with ethyl ether and isolated by filtration. The solid was then slurried in hot acetone, cooled and refiltered to yield the solid named above which decomposed at 180°-182°.

後処理

  1. customthe white semisolid residue triturated with ethyl ether
  2. customisolated by filtration
  3. temperaturecooled
  4. customto yield the solid
  5. customdecomposed at 180°-182°

出典と根拠

ORDレコード
ord-b4614a42cfa24a8fbd0ddc680ef7c32b
出典データセット
uspto-grants-1980_11
特許番号
US04231784

関連ノート

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