Hydroxyamine hydrochloride → N'-hydroxy-3-(hydroxymethyl)benzimidamide

HRID 2242245ノート

反応式

HRID 2242245 の反応式
Cl.[OH:2][NH2:3].C(=O)(O)[O-].[Na+].[OH:9][CH2:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[C:14]#[N:15]>CO>[OH:2][N:3]=[C:14]([C:13]1[CH:16]=[CH:17][CH:18]=[C:11]([CH2:10][OH:9])[CH:12]=1)[NH2:15]

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 27346773-(Hydroxymethyl)benzonitrile

生成物 1

HCID 74865044N'-hydroxy-3-(hydroxymethyl)benzimidamide収率 105.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Hydroxyl amine hydrochloride (2.29 g, 32.9 mmol) and sodium bicarbonate (5.52 g, 65.8 mmol) were added to 3-(hydroxymethyl)benzonitrile (2.19 g, 16.4 mmol) and methanol (30 mL) and stirred at reflux for 18 hours. The reaction mixture was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo to give the title compound (2.88 g, 100% yield) as a solid.

後処理

  1. temperatureat reflux for 18 hours
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-50dca5ceb82844329cd1beb4a8475d8a
出典データセット
uspto-grants-2010_03
特許番号
US07671043B2

反応ノート

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