Hydrochloric Acid → HCID 178440786、化合物

HRID 2242254ノート

反応式

HRID 2242254 の反応式
[OH-].[Na+].[CH2:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:17]=[C:16]([C:18]3[CH:34]=[CH:33][C:21]([CH2:22][NH:23][C@@H:24]4[CH2:27][C@H:26]([C:28]([O:30]CC)=[O:29])[CH2:25]4)=[CH:20][CH:19]=3)[O:15][N:14]=2)=[CH:9][CH:8]=1)[CH:4]([CH3:6])[CH3:5].[ClH:35]>C(O)C>[ClH:35].[CH2:3]([C:7]1[CH:8]=[CH:9][C:10]([C:13]2[N:17]=[C:16]([C:18]3[CH:34]=[CH:33][C:21]([CH2:22][NH:23][C@@H:24]4[CH2:27][C@H:26]([C:28]([OH:30])=[O:29])[CH2:25]4)=[CH:20][CH:19]=3)[O:15][N:14]=2)=[CH:11][CH:12]=1)[CH:4]([CH3:6])[CH3:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178472516HCID 178472516、化合物

生成物 1

HCID 178440786HCID 178440786、化合物収率 41%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

1N NaOH (3.00 g, 3.00 mmol) was added to a solution of ethyl cis-3-({4-[3-(4-isobutylphenyl)-1,2,4-oxadiazol-5-yl]benzyl}amino)cyclobutanecarboxylate (0.260 g, 0.600 mmol) and ethanol (2 mL) and heated to 100° C. in a microwave for 5 minutes. The reaction mixture was adjusted to pH of 7 with 1N HCl causing a white precipitate to form. The reaction mixture was filtered and the solid was slurried in ethyl acetate and treated with 1 N HCl in ether. The slurry was filtered and washed with petroleum ether to give the title compound (0.100 g, 41% yield) as a white solid.

後処理

  1. customto form
  2. filtrationThe reaction mixture was filtered
  3. additiontreated with 1 N HCl in ether
  4. filtrationThe slurry was filtered
  5. washwashed with petroleum ether

出典と根拠

ORDレコード
ord-5417227a5ffb43a6ad91fa67e72e526d
出典データセット
uspto-grants-2010_03
特許番号
US07671043B2

反応ノート

読み込み中…