Hydrochloric Acid → HCID 178440783、化合物

HRID 2242258ノート

反応式

HRID 2242258 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([O:28]CC)=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].[ClH:35]>CO>[ClH:35].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([OH:28])=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178472517HCID 178472517、化合物

生成物 1

HCID 178440783HCID 178440783、化合物収率 61%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of ethyl cis-3-({4-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}amino)cyclobutane carboxylate (0.300 g, 0.692 mmol), 1N NaOH (6.0 mL), and methanol (5 mL) was heated in a microwave oven at 100° C. for 3 minutes. The reaction mixture was cooled to room temperature and pH was adjusted to 7 with 1N HCl, causing a white solid to precipitate. The reaction mixture was filtered and the solid was washed with water, then treated with 1N HC in ether to give the title compound (0.170 g, 61% yield).

後処理

  1. customto precipitate
  2. filtrationThe reaction mixture was filtered
  3. washthe solid was washed with water
  4. additiontreated with 1N HC in ether

出典と根拠

ORDレコード
ord-54b445a372f3416ea4b1d310f9d5982e
出典データセット
uspto-grants-2010_03
特許番号
US07671043B2

反応ノート

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