C([O:5][C:6](=[O:59])[C@@H:7]([NH:11][C:12]([C@@H:14]1[CH2:18][C@@H:17]([O:19][C:20]2[C:29]3[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][CH:28]=3)[N:23]=[C:22]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:21]=2)[CH2:16][C@H:15]1[C:38](=[O:58])[NH:39][C@H:40]([C:44](=[O:57])[NH:45][C@@H:46]([CH:51]1[CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]1)[C:47]([O:49][CH3:50])=[O:48])[CH:41]([CH3:43])[CH3:42])=[O:13])[CH2:8][CH2:9][CH3:10])(C)(C)C.C([SiH](CC)CC)C>C(Cl)Cl.FC(F)(F)C(O)=O>[CH:51]1([C@H:46]([NH:45][C:44]([C@@H:40]([NH:39][C:38]([C@@H:15]2[CH2:16][C@H:17]([O:19][C:20]3[C:29]4[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[CH:21]=3)[CH2:18][C@H:14]2[C:12]([NH:11][C@@H:7]([CH2:8][CH2:9][CH3:10])[C:6]([OH:59])=[O:5])=[O:13])=[O:58])[CH:41]([CH3:42])[CH3:43])=[O:57])[C:47]([O:49][CH3:50])=[O:48])[CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]1Tert.butyl ester 56 (28 mg, 0.034 mmol) and triethylsilane (14 μL, 0.088 mmol) was dissolved in DCM (2 mL) after which trifluoroacetic acid (2 mL) was added and the mixture was stirred for 2 h. Co-evaporation with toluene gave 57 (26 mg, 100%) as a colorless solid.
読み込み中…