Trifluoroacetic acid → 2-Furan-2-yl-6-piperazin-1-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

HRID 2242908ノート

反応式

HRID 2242908 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[C:16]([NH:28]C(OC(C)(C)C)=O)[C:17]3[N:18]([N:20]=[C:21]([C:23]4[O:24][CH:25]=[CH:26][CH:27]=4)[N:22]=3)[CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[O:24]1[CH:25]=[CH:26][CH:27]=[C:23]1[C:21]1[N:22]=[C:17]2[C:16]([NH2:28])=[N:15][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:19][N:18]2[N:20]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 685441504-(8-Tert-butoxycarbonylamino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 111619332-Furan-2-yl-6-piperazin-1-yl-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-(8-tert-butoxycarbonylamino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-piperazine-1-carboxylic acid tert-butyl ester (140 mg, 0.29 mmol; see Example 16 (i) above) in methylene chloride (4 mL) was added trifluoroacetic acid (400 μL). The reaction was stirred at room temperature for 2 hours. After the solvent and extra trifluoroacetic acid was evaporated, the residue was dissolved in methylene chloride (4 mL). The title compound in methylene chloride was divided into two portions and used for further reactions (see Example 17 and Example 18 below) without further purification.

後処理

  1. customAfter the solvent and extra trifluoroacetic acid was evaporated
  2. dissolutionthe residue was dissolved in methylene chloride (4 mL)
  3. customused for further reactions (see Example 17 and Example 18 below) without further purification

出典と根拠

ORDレコード
ord-c8aa57986f73411abc9241d510029279
出典データセット
uspto-grants-2010_03
特許番号
US07674791B2

反応ノート

読み込み中…