To a stirred solution of ethyl 2-[6-(3-ethyl-ureido)-pyridin-3-yl]-4-isopropylcarbamoyl-thiazole-5-carboxylate (Example 65, 0.195 g, 0.48 mmol) in methanol (7 mL) was added 2 N lithium hydroxide (2 mL). The mixture was heated to 50° C. overnight, then concentrated to dryness water was added and the pH was adjusted to pH 2 with 2N hydrochloric acid. The precipitated solid was filtered and dried under vacuum to afford 0.15 g (76.2%) of the title compound as a solid. NMR: 1.11 (t, 3H), 1.28 (d, 6H), 3.22 (q, 2H), 4.20 (m, 1H), 7.62 (d, 1H), 7.7 (r bs, 1H), δ 8.42 (dd, 1H), 8.57 (d, 1H), δ 9.03 (s, 1H).
