Thionyl Chloride → Ethyl 2-chloro-4-(chlorocarbonyl)-1,3-thiazole-5-carboxylate
反応式
[Cl:1][C:2]1[S:3][C:4]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:5]([C:7](O)=[O:8])[N:6]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[S:3][C:4]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:5]([C:7]([Cl:17])=[O:8])[N:6]=1参加物
3
実験手順
2-Chloro-5-(ethoxycarbonyl)-1,3-thiazole-4-carboxylic acid (Intermediate 7, 1 g, 4.24 mmol) was dissolved in thionyl chloride (5 mL) and refluxed for two hours. It was then concentrated to give the desired product (light brown oil, 1 g). NMR (CDCl3): 1.37 (t, 3H), 4.39 (q, 2H).
後処理
- temperaturerefluxed for two hours
- concentrationIt was then concentrated
出典と根拠
- ORDレコード
- ord-687a1ecbf229478b948212be5b9c9ea0
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07674801B2
反応ノート
読み込み中…