Ethyl isocyanate → 1-(4-Bromopyridin-2-yl)-3-ethylurea

HRID 2243060ノート

反応式

HRID 2243060 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[N:9]([CH2:12][CH3:13])=[C:10]=[O:11]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:10]([NH:9][CH2:12][CH3:13])=[O:11])[CH:3]=1

参加物

4

反応物 2

HCID 8022Ethyl isocyanateHCID 6932822-Amino-4-bromopyridine

生成物 1

HCID 592083771-(4-Bromopyridin-2-yl)-3-ethylurea収率 76.2%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
110 °C

実験手順

To a mixture of 4-bromopyridin-2-amine (2 g, 11.56 mmol) in chloroform (10 mL), isocyanatoethane (0.913 mL, 11.56 mmol) was added, and the resulting reaction mixture was heated at 110° C. for 2 h. The reaction mixture was concentrated under reduced pressure and triturated with acetonitrile, then collected by filtered to give the title compound as a white solid (2.15 g).

後処理

  1. additionwas added
  2. customthe resulting reaction mixture
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customtriturated with acetonitrile
  5. customcollected
  6. filtrationby filtered

出典と根拠

ORDレコード
ord-45a5880b52564e1bb2cf746037031595
出典データセット
uspto-grants-2010_03
特許番号
US07674801B2

反応ノート

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