1H-1,2,4-Triazole → 1-(4-Fluorobenzyl)-1H-1,2,4-triazole

HRID 2243133

反応式

HRID 2243133 の反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Br)=[CH:9][CH:8]=1.N12CCCN=C1CCCCC2>C1COCC1>[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 92571H-1,2,4-TriazoleHCID 680214-Fluorobenzyl bromideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

生成物 1

HCID 232736751-(4-Fluorobenzyl)-1H-1,2,4-triazole収率 68%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 1,2,4-triazole (0.803 g, 11.6 mmol) in THF (100 mL) at 0° C. was added 4-fluorobenzyl bromide (2.0 g, 10.6 mmol), then 1,8-diazabicyclo[5.4.0]undec-7-ene (1.9 mL, 12.7 mmol) and the mixture was slowly warmed to room temperature. The solution was concentrated in vacuo, then purified by column chromatography (SiO2, MeOH/EtOAc, 5:95) to yield a white solid in 68% yield.

後処理

  1. concentrationThe solution was concentrated in vacuo
  2. custompurified by column chromatography (SiO2, MeOH/EtOAc, 5:95)
  3. customto yield a white solid in 68% yield

出典と根拠

ORDレコード
ord-61547b02120a4c1787c65a6c2cd437c3
出典データセット
uspto-grants-2010_03
特許番号
US07674813B2

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