Iodine → HCID 178506332、化合物

HRID 2243279

反応式

HRID 2243279 の反応式
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[N+]([O-])([O-])=O.[NH4+].[Ce].[Ce].[I:20]I>C(#N)C>[I:20][C:11]1[C:7]([C:2]([F:1])([F:12])[C:3]([F:6])([F:5])[F:4])=[N:8][NH:9][CH:10]=1

参加物

5

反応物 3

HCID 807IodineHCID 86617141Dicerium ammonium nitrateHCID 1785063263-(pentafluoroethyl)-1H-pyrazole

生成物 1

HCID 178506332HCID 178506332、化合物収率 162.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

An acetonitrile solution (20 ml) of 3-pentafluoroethyl-1H-pyrazole (2.0 g), dicerium ammonium nitrate (3.0 g) and iodine (1.6 g) was refluxed for 3 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-3-pentafluoroethyl-1H-pyrazole (3.2 g).

後処理

  1. temperatureAfter cooling
  2. washthe reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride
  3. dry with materialAfter drying the organic layer with magnesium sulfate
  4. distillationthe solvent was distilled off under the reduced pressure

出典と根拠

ORDレコード
ord-616beeebfdde422abc9d876986fc83e7
出典データセット
uspto-grants-2010_03
特許番号
US07674807B2

関連ノート

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