Methyl (7E)-8-{2-[(4-cyclohexylbenzyl)oxy]phenyl}-6-oxo-7-octenoate → Methyl 8-{2-[(4-cyclohexylbenzyl)oxy]phenyl}-6-oxooctanoate

HRID 2243295ノート

反応式

HRID 2243295 の反応式
[CH:1]1([C:7]2[CH:32]=[CH:31][C:10]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3/[CH:19]=[CH:20]/[C:21](=[O:30])[CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[CH:1]1([C:7]2[CH:32]=[CH:31][C:10]([CH2:11][O:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH2:19][CH2:20][C:21](=[O:30])[CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 59210853Methyl (7E)-8-{2-[(4-cyclohexylbenzyl)oxy]phenyl}-6-oxo-7-octenoate

生成物 1

HCID 59210668Methyl 8-{2-[(4-cyclohexylbenzyl)oxy]phenyl}-6-oxooctanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A suspension of 2.80 g (6.44 mmol) of methyl (7E)-8-{2-[(4-cyclohexylbenzyl)-oxy]phenyl}-6-oxo-7-octenoate XIII and 0.06 g of Pd/C (10% Pd) in 30 ml of ethyl acetate was stirred under an atmosphere of hydrogen for 3 h. The catalyst was removed by filtration through Celite, and the product was purified chromatographically (silica gel, cyclohexane/ethyl acetate 20:1).

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. customthe product was purified chromatographically (silica gel, cyclohexane/ethyl acetate 20:1)

出典と根拠

ORDレコード
ord-43abae2605a64014a979ea4f6756e320
出典データセット
uspto-grants-2010_03
特許番号
US07674825B2

反応ノート

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