Lithium Hydroxide → HCID 11545923、化合物
反応式
C[O:2][C:3]([C:5]1[S:23][C:8]2[C:9]3[CH:10]=[CH:11][CH:12]=[C:13]([NH:16][CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[C:14]=3[S:15][C:7]=2[C:6]=1[O:24][CH2:25][C:26]([O:28]CC)=[O:27])=[O:4].[Li+].[OH-]>C1COCC1.O>[C:26]([CH2:25][O:24][C:6]1[C:7]2[S:15][C:14]3[C:13]([NH:16][CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[S:23][C:5]=1[C:3]([OH:4])=[O:2])([OH:28])=[O:27]参加物
4
実験手順
Step C Hydrolysis: To a solution of 7-Cyclohexylamino-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester (30 mg, 0.07 mmol) in THF/H2O (1.5 mL/0.5 mL) was added 2.0M LiOH (0.15 mL, 0.35 mmol). The reaction was allowed to stir at ambient temperature over a 16-hour period, after which it was judged complete by LCMS. The THF was removed in vacuo and the resultant aqueous solution was acidified to pH ˜1-2 using 10% HCl to precipitate the desired compound which was filtered, rinsed with water, and oven-dried (55° C.). No purification was necessary. (Yield=20 mg, 71%)