Methyl iodide → 4-(Ethoxycarbonyl)-1-methylpyridin-1-ium iodide
反応式
[CH2:1]([O:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:12][I:13]>C(O)C>[I-:13].[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[CH:7][N+:8]([CH3:12])=[CH:9][CH:10]=1)=[O:11])[CH3:2]参加物
4
反応条件
- 温度
- 60 °C
実験手順
Isonicotinic acid ethyl ester (5 g, 33 mmol), was dissolved in ethanol (40 mL). Methyl iodide (4.13 mL, 66.1 mmol) was added and the clear solution was stirred overnight at 60° C. The resulting mixture was evaporated to yield a red/orange solid, which was determined by 1H NMR and thin-layer chromatography (TLC) to be the title product in quantitative yield. The crude mixture was used directly in the following reaction.
後処理
- customThe resulting mixture was evaporated
- customto yield a red/orange solid, which
出典と根拠
- ORDレコード
- ord-ab734f30b046489eb0d2914a156f5deb
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07678796B2
反応ノート
読み込み中…