Hydrazine hydrate (1:1) → 1-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazide

HRID 2243889ノート

反応式

HRID 2243889 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]([CH3:11])[C:7](=[O:12])[CH:6]=1)=O.O.[NH2:14][NH2:15]>C(O)C>[CH3:11][N:8]1[CH:9]=[CH:10][C:5]([C:3]([NH:14][NH2:15])=[O:2])=[CH:6][C:7]1=[O:12]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 819408Methyl 1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

生成物 1

HCID 431322131-Methyl-2-oxo-1,2-dihydropyridine-4-carbohydrazide収率 78.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
78 °C

実験手順

The title compound of example 24 (4.0 g, 23.9 mmol) was dissolved in ethanol (50 mL). Hydrazine hydrate (5.8 mL, 119 mmol) was added and the reaction was stirred at 78° C. for 3 hours. The reaction mixture was then cooled to room temperature and the product was filtered off to give 3.13 g (78% yield) of the title compound as a light yellow solid.

後処理

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. filtrationthe product was filtered off

出典と根拠

ORDレコード
ord-6e985cf53a5940caab4753b815de760d
出典データセット
uspto-grants-2010_03
特許番号
US07678796B2

反応ノート

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