Hydrazine hydrate (1:1) → 3-(5-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

反応式

[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C:27]([F:30])([F:29])[F:28])=O)(=O)OC.O.[NH2:32][NH2:33]>>[F:26][C:24]1[CH:23]=[CH:22][C:21]([C:27]([F:30])([F:29])[F:28])=[C:20]([C:18]2[N:33]=[N:32][C:2]3[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=3[CH:17]=2)[CH:25]=1

参加物

反応物 3

HCID 24654Hydrazine hydrate (1:1)

HCID 5436981,2-Cyclooctanedione

HCID 86609914[2-(5-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

生成物 1

HCID 670149543-(5-Fluoro-2-trifluoromethyl-phenyl)-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

実験手順

yellow oil. MS (EI): 324.2 (M+). Prepared from cyclooctane-1,2-dione, [2-(5-Fluoro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

出典と根拠

ORDレコード: ord-b51d544d607340738419208d89fad1e8
出典データセット: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07678795B2

反応ノート

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