3-(2-Benzyloxyethyl)oxazolidin-2-one → 2-Oxazolidinone, 3-(2-hydroxyethyl)-
反応式
C([O:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16])C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[OH:8][CH2:9][CH2:10][N:11]1[CH2:15][CH2:14][O:13][C:12]1=[O:16]参加物
4
実験手順
20% palladium hydroxide (138 mg) was added to a solution of 3-(2-benzyloxyethyl)oxazolidin-2-one (278 mg) in methanol (10 ml), and the mixture was stirred for 2 hours at room temperature under hydrogen atmosphere. The reaction solution was filtered through celite and then the solvent was evaporated. The residue was purified by silica gel column chromatography (chloroform:methanol=90:10) to yield 3-(2-hydroxyethyl)oxazolidin-2-one (144 mg) as a colorless oil.
後処理
- filtrationThe reaction solution was filtered through celite
- customthe solvent was evaporated
- customThe residue was purified by silica gel column chromatography (chloroform:methanol=90:10)
出典と根拠
- ORDレコード
- ord-e18f69abbc194a298e0adda475a01e70
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07678810B2
反応ノート
読み込み中…