Acetaldehyde → 4-(1-Fluorocyclopropyl)benzoic acid

HRID 2244327ノート

反応式

HRID 2244327 の反応式
[O:1]=O.[F:3][C:4]1([C:7]2[CH:12]=[CH:11]C(C)=[CH:9][CH:8]=2)[CH2:6][CH2:5]1.[CH:14](=[O:16])[CH3:15]>C(O)(=O)C.O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C>[F:3][C:4]1([C:7]2[CH:12]=[CH:11][C:15]([C:14]([OH:1])=[O:16])=[CH:9][CH:8]=2)[CH2:6][CH2:5]1

参加物

6

反応物 3

HCID 177AcetaldehydeHCID 977OxygenHCID 68703601HCID 68703601、化合物

生成物 1

HCID 665992344-(1-Fluorocyclopropyl)benzoic acid収率 46%

試薬・触媒・溶媒 2

HCID 61372Cobalt(II) acetate tetrahydrate触媒HCID 176Acetic Acid溶媒

実験手順

Oxygen was slowly bubbled at 100° C. through a solution of 1-(1-fluoro-cyclopropyl)-4-methyl-benzene (470 mg, 3.13 mmol), cobalt(II)acetate tetrahydrate (117 mg, 0.46 mmol), and acetaldehyde (0.18 mL, 3.1 mmol) in acetic acid (30 mL) over 16 h. After cooling, the reaction mixture was evaporated and the residue triturated in water. The precipitate was collected by filtration to produce the title compound (257 mg, 46%). Light green solid, MS (EI) 180.1 (M+).

後処理

  1. temperatureAfter cooling
  2. customthe reaction mixture was evaporated
  3. customthe residue triturated in water
  4. filtrationThe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-61b79f41742d4eef8ce098b7f76c38d3
出典データセット
uspto-grants-2010_03
特許番号
US07678818B2

反応ノート

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