Sodium Hydroxide → 6-(Fluoromethyl)pyridin-2-amine
反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][F:15])[N:9]=1)(C)(C)C.[OH-].[Na+]>Cl>[F:15][CH2:14][C:10]1[N:9]=[C:8]([NH2:7])[CH:13]=[CH:12][CH:11]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
A suspension of (6-fluoromethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (0.10 g, 0.43 mmol) in 6N HCl (2.00 ml) was warmed to 100° C. and stirred for 6 h. The clear solution was then cooled to room temperature and neutralized with 5N NaOH. The aqueousaqueous phase was extracted several times with dichloromethane. The combined organic phases were dried over sodium sulfate and evaporated to yield 6-fluoromethyl-pyridin-2-ylamine (0.04 g, 78%) as colorless oil, which was used crude.
後処理
- extractionThe aqueousaqueous phase was extracted several times with dichloromethane
- dry with materialThe combined organic phases were dried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-a6a40b2f4c714cb1bbc0bd80d7a98311
- 出典データセット
- uspto-grants-2010_03
- 特許番号
- US07678815B2
反応ノート
読み込み中…