HCID 58674939、化合物 → HCID 58674940、化合物

HRID 2244419ノート

反応式

HRID 2244419 の反応式
[CH3:1][C:2]1[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=[C:4]([N+:12]([O-])=O)[N:3]=1>C(O)C.[Pd]>[NH2:12][C:4]1[N:3]=[C:2]([CH3:1])[C:7]([O:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 58674939HCID 58674939、化合物

生成物 1

HCID 58674940HCID 58674940、化合物収率 95%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Acetic acid 2-methyl-6-nitro-pyridin-3-yl ester (0.30 g, 1.53 mmol) was dissolved in ethanol. 10% Pd/C (0.04 g, 0.38 mmol) was added, and the mixture was put under an atmosphere of hydrogen and stirred vigorously for 50 min at room temperature. The catalyst was filtered off, washing with ethanol, and the solvent removed under vacuum to yield acetic acid 6-amino-2-methyl-pyridin-3-yl ester (0.24 g, 95%) as a white solid, MS (ISP): m/e=166.2 (M+), which was used crude.

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashing with ethanol
  3. customthe solvent removed under vacuum

出典と根拠

ORDレコード
ord-197da1023afe4f79ba48c26dc27c8dcd
出典データセット
uspto-grants-2010_03
特許番号
US07678815B2

反応ノート

読み込み中…