Tetrahydrofuran → HCID 44156297、化合物

HRID 2244463ノート

反応式

HRID 2244463 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH:14]=[C:13]([Si](C)(C)C)[N:12]=[N:11]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1COCC1>C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH:14]=[CH:13][N:12]=[N:11]2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 8028TetrahydrofuranHCID 684073741-(3-Nitro-phenyl)-4-trimethylsilanyl-1H-[1,2,3]triazole

生成物 1

HCID 44156297HCID 44156297、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

1-(3-Nitro-phenyl)-4-trimethylsilanyl-1H-[1,2,3]triazole (16.7 g, 64 mmol) tetrabutylammonium fluoride in THF (1M, 100 ml, 100 mmol) were stirred at room temperature for 24 h. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic layer was dried with magnesium sulfate, filtered and evaporated. The crude product was purified by chromatography on silica gel (hexane/ethyl acetate 1:1) and the desired product was obtained as a brown solid (9.96 g, 82%), mp 80-83° C.

後処理

  1. washwashed with water and brine
  2. dry with materialThe organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customevaporated
  5. customThe crude product was purified by chromatography on silica gel (hexane/ethyl acetate 1:1)

出典と根拠

ORDレコード
ord-caf0695b9ce4428eada68a063e578432
出典データセット
uspto-grants-2010_03
特許番号
US07678815B2

反応ノート

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