Piperazine → 6-Piperazin-1-ylbenzo[b][1,4]benzothiazepine;hydrochloride

HRID 2244553

反応式

HRID 2244553 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14][C:15]1[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=1[C:17](O)=O.[ClH:24].C(O)C>C(O)C>[ClH:24].[N:1]1([C:17]2[C:16]3[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=3[S:14][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[N:7]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 4837PiperazineHCID 109558282-((2-Aminophenyl)thio)benzoic acidHCID 21887872Ethanol hydrochloride

生成物 1

HCID 162023916-Piperazin-1-ylbenzo[b][1,4]benzothiazepine;hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Piperazine (53.6 g) was added to the resulting toluene solution, reflux was conducted for 1 hour, and the resulting solution was cooled to room temperature. Washing was carried out with water (125 ml×3) to remove remaining piperazine, and an organic layer was vacuum distilled to produce oil. The oil was dissolved in ethanol, and a hydrochloric acid-ethanol solution was added thereto, to produce 11-piperazinyl-dibenzo[b,f][1,4]thiazepine hydrochloride (46.4 g).

後処理

  1. temperaturereflux
  2. washWashing
  3. customto remove
  4. distillationdistilled
  5. customto produce oil

出典と根拠

ORDレコード
ord-2d64ab1928814662957eceaed8ad3f9d
出典データセット
uspto-grants-2010_03
特許番号
US07678902B2

関連ノート

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