Sodium Hydroxide → 1-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

HRID 2244621ノート

反応式

HRID 2244621 の反応式
[OH-].[Na+].[CH2:3]([N:7]1[CH:12]=[CH:11][C:10]([C:13]([O:15]C)=[O:14])=[CH:9][C:8]1=[O:17])[CH:4]([CH3:6])[CH3:5]>CO.C1COCC1>[CH2:3]([N:7]1[CH:12]=[CH:11][C:10]([C:13]([OH:15])=[O:14])=[CH:9][C:8]1=[O:17])[CH:4]([CH3:6])[CH3:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59214340HCID 59214340、化合物

生成物 1

HCID 446005741-Isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid収率 81%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

To a mixed solution was added a 1M aqueous NaOH solution (4.1 ml) of methyl 1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylate (430 mg) in CH3OH-THF (4 ml-3 ml). The solution was stirred at room temperature for 10 hours, and then concentrated under reduced pressure, and water (10 ml) was added, and subsequently 1M HCl was added thereto until pH becomes 3. The resulting solid was collected by filtration, washed with water, and dried under reduced pressure to obtain 1-isobutyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (325 mg) as white powders.

後処理

  1. concentrationconcentrated under reduced pressure, and water (10 ml)
  2. additionwas added
  3. additionsubsequently 1M HCl was added
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with water
  6. customdried under reduced pressure

出典と根拠

ORDレコード
ord-8fed1637ad2c4ac682ff19acfd8a4e98
出典データセット
uspto-grants-2010_03
特許番号
US07678820B2

反応ノート

読み込み中…