1,2-Dichloroethane → N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-(2,2-dimethylpropyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide

HRID 2244964ノート

反応式

HRID 2244964 の反応式
[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C@@H:4]([C:6]([OH:8])=O)[NH2:5].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=1.[CH3:21][N:22]1[CH2:26][CH2:25][N:24]=[C:23]1[C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=1.C(Cl)CCl>CN(C=O)C.O>[CH3:21][N:22]1[CH2:26][CH2:25][N:24]=[C:23]1[C:27]1[CH:32]=[CH:31][C:30]([NH:33][C:6](=[O:8])[CH:4]([CH2:3][C:2]([CH3:1])([CH3:10])[CH3:9])[NH:5][C:19]([NH:18][C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][CH:14]=2)=[O:20])=[CH:29][CH:28]=1

参加物

7

反応物 4

HCID 111,2-DichloroethaneHCID 76934-Chlorophenyl IsocyanateHCID 194032(2S)-2-Amino-4,4-dimethylpentanoic acidHCID 227288764-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine

生成物 1

HCID 11619441N-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenyl]-2-(2,2-dimethylpropyl)-2-(4-chlorophenylaminocarbonylamino)-acetamide収率 51.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of DL-γ-methylleucine (48 mg, 0.33 mmol) in DMF (2 mL), 4-chlorophenyl isocyanate (50 mg, 0.33 mmol) was added. The mixture was then stirred at room temperature overnight. To the reaction mixture, 4-(1-Methyl-4,5-dihydro-1H-imidazol-2-yl)-phenylamine (150 mg, 0.86 mmol) and H2O (0.5 mL, to solubilize the amine) were added. To the solution, EDC (127 mg, 0.66 mmol) was added. After being stirred at room temperature overnight, the solution was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (77 mg). MS 456.2 and 458.2 (M+H, Cl pattern).

後処理

  1. additionwere added
  2. stirringAfter being stirred at room temperature overnight
  3. concentrationthe solution was concentrated in vacuo
  4. customThe residue was purified by HPLC

出典と根拠

ORDレコード
ord-a345ab8f0ba0495198f2a0545a6e7e11
出典データセット
uspto-grants-2010_03
特許番号
US07678913B2

反応ノート

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