Ethyl 4-piperidinecarboxylate → Ethyl 1-{[4-(2-ethyl-1,2,3,4-tetraazol-5-yl)phenyl]methyl}piperidine-4-carboxylate

HRID 2245320ノート

反応式

HRID 2245320 の反応式
[NH:1]1[CH2:11][CH2:10][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:3][CH2:2]1.C(N(CC)C(C)C)(C)C.Br[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[N:30]=[N:31][N:32]([CH2:34][CH3:35])[N:33]=2)=[CH:25][CH:24]=1>CS(C)=O.CO.C(OCC)(=O)C>[CH2:34]([N:32]1[N:31]=[N:30][C:29]([C:26]2[CH:27]=[CH:28][C:23]([CH2:22][N:1]3[CH2:2][CH2:3][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:10][CH2:11]3)=[CH:24][CH:25]=2)=[N:33]1)[CH3:35]

参加物

7

反応物 3

HCID 70770Ethyl 4-piperidinecarboxylateHCID 81531DiisopropylethylamineHCID 686826535-[4-(Bromomethyl)phenyl]-2-ethyl-1,2,3,4-tetraazole

生成物 1

HCID 21260416Ethyl 1-{[4-(2-ethyl-1,2,3,4-tetraazol-5-yl)phenyl]methyl}piperidine-4-carboxylate収率 71.6%

試薬・触媒・溶媒 3

HCID 679Dimethyl Sulfoxide溶媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 16.0 grams (0.102 mole) of ethyl isonipecotate in 50 mL of DMSO and 66 mL of methanol was stirred, and 44 mL (0.256 mole) of N,N-diisopropylethylamine, followed by 22.8 grams (0.085 mole) of 5-[4-(bromomethyl)phenyl]-2-ethyl-1,2,3,4-tetraazole were added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for about 72 hours. After this time, the reaction mixture was diluted with 130 mL of ethyl acetate, and washed with a 1:1 solution of an aqueous solution saturated with sodium chloride and water. The organic layer was then washed with an aqueous solution saturated with sodium chloride and water, dried with sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to a residue. The residue was purified with column chromatography on silica gel using mixtures of methylene chloride and acetone. The appropriate fractions were combined and concentrated under reduced pressure, yielding 20.9 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

後処理

  1. additionwere added
  2. additionUpon completion of addition
  3. washwashed with a 1:1 solution of an aqueous solution saturated with sodium chloride and water
  4. washThe organic layer was then washed with an aqueous solution saturated with sodium chloride and water
  5. dry with materialdried with sodium sulfate
  6. filtrationfiltered
  7. concentrationThe filtrate was concentrated under reduced pressure to a residue
  8. customThe residue was purified with column chromatography on silica gel using mixtures of methylene chloride and acetone
  9. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-50ad921b9bb24eb2b2094df83f2925b7
出典データセット
uspto-grants-2010_03
特許番号
US07683070B2

反応ノート

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