Dextroamphetamine → 4-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

HRID 224565

反応式

HRID 224565 の反応式
[CH3:1][C@H:2]([NH2:10])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1.C(N(CC)CC)C.[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>C1C=CC=CC=1>[C:18]1([CH3:28])[CH:23]=[CH:22][C:21]([S:24]([NH:10][CH:2]([CH3:1])[CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 5826DextroamphetamineHCID 73974-Toluenesulfonyl chlorideHCID 8471Triethylamine

生成物 1

HCID 132498614-Methyl-N-(1-methyl-2-phenylethyl)benzenesulfonamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

Dextro amphetamine (200 g) and triethylamine (164 g) were dissolved in 1500 ml. of benzene. A solution of p-toluene sulfonyl chloride (310g) in 500 ml. of benzene was added dropwise to the cooled solution during one hour. The reaction mixture was stirred for three hours at room temperature, then allowed to stand for approximately 16 hours (over night) at room temperature (approximately 20° C.). The salts were filtered off and the benzene solution was washed with dilute HCl, water and brine. Evaporation of the solvent afforded an oil.

後処理

  1. waitto stand for approximately 16 hours
  2. customat room temperature
  3. custom(approximately 20° C.)
  4. filtrationThe salts were filtered off
  5. washthe benzene solution was washed with dilute HCl, water and brine
  6. customEvaporation of the solvent
  7. customafforded an oil

出典と根拠

ORDレコード
ord-b403412b2678470f8919b8be94d0df2d
出典データセット
uspto-grants-1980_11
特許番号
US04233217

関連ノート

読み込み中…