6-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione → 5,6-Diamino-3-methyl-1-phenyluracil

HRID 224584ノート

反応式

HRID 224584 の反応式
[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6](=[O:14])[N:5]([CH3:15])[C:4](=[O:16])[C:3]=1[N:17]=O>CN(C=O)C.O=[Pt]=O>[NH2:17][C:3]1[C:4](=[O:16])[N:5]([CH3:15])[C:6](=[O:14])[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:2]=1[NH2:1]

参加物

4

反応物 1

HCID 127062666-Amino-3-methyl-5-nitroso-1-phenylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 110752755,6-Diamino-3-methyl-1-phenyluracil

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 6228Dimethylformamide溶媒

実験手順

40.5 g of 6-amino-3-methyl-5-nitroso-1-phenyl-2,4-(1H, 3H)-pyrimidinedione (XVII) in 500 ml of DMF and in the presence of 0.3 g of PtO2 was the solution catalytically hydrogenated for 20 minutes at a pressure of 200 kPa. The reaction mixture was heated and the catalyst was filtered off. After cooling, crystals were filtered off and washed with DMF and water. Yield 21.4 g (XVIII). NMR

後処理

  1. temperatureThe reaction mixture was heated
  2. filtrationthe catalyst was filtered off
  3. temperatureAfter cooling
  4. filtrationcrystals were filtered off
  5. washwashed with DMF and water

出典と根拠

ORDレコード
ord-baedd3dcaa8d4d59add7c0c3ecd6ac79
出典データセット
uspto-grants-1980_11
特許番号
US04233303

反応ノート

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