Hydrochloric Acid → 4-Aminomethylisophthalic acid

HRID 2246033ノート

反応式

HRID 2246033 の反応式
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([OH:14])=[O:13])#[N:2].Cl>[Pd].C(O)C>[NH2:2][CH2:1][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([OH:14])=[O:13]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 226444314-Cyanoisophthalic acid

生成物 1

HCID 226444344-Aminomethylisophthalic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A pressure flask was charged with 4-cyanoisophthalic acid 204 (1.40 g, 7.33 mmol), ethanol (100 mL), Pd/C (10%) (0.50 mg), and concentrated HCl (1.5 mL). The mixture solution was hydrogenated at 50 PSI overnight. The solid impurities were removed by filtration. Removal of solvent gave quantitative yield of 4-aminomethylisophthalic acid 205: 1H NMR (400 MHz, CD3OD) δ 4.46 (s, 2H), 7.69 (d, J=8 Hz, 1H), 8.26 (dd, J=2 Hz, J=8 Hz, 1H), 8.76 (d, J=1.7 Hz, 1H).

後処理

  1. customwas hydrogenated at 50 PSI overnight
  2. customThe solid impurities were removed by filtration
  3. customRemoval of solvent

出典と根拠

ORDレコード
ord-1241d288087b4671982749bf792abed0
出典データセット
uspto-grants-2010_03
特許番号
US07687236B2

反応ノート

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