Hydrogen Bromide → Meloxicam

HRID 224609ノート

反応式

HRID 224609 の反応式
Br.C[O:3][C:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[S:7](=[O:15])(=[O:14])[N:6]([CH3:16])[C:5]=1[C:17]([NH:19][C:20]1[S:21][C:22]([CH3:25])=[CH:23][N:24]=1)=[O:18]>C(O)(=O)C>[OH:3][C:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[S:7](=[O:15])(=[O:14])[N:6]([CH3:16])[C:5]=1[C:17]([NH:19][C:20]1[S:21][C:22]([CH3:25])=[CH:23][N:24]=1)=[O:18]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 23331598O-Methyl Meloxicam

生成物 1

HCID 54677470Meloxicam

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

0.5 ml of 48% hydrobromic acid and 1 ml of glacial acetic acid were added to 0.2 gm (0.55 millimols) of 4-methoxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-caboxamide-1,1-dioxide. After standing for 24 hours, the reaction mixture was heated for two hours on a water bath and was subsequently evaporated in vacuo to dryness. The residue was dissolved in methylene chloride, and the solution was washed with water. After drying and evaporating of the organic phase, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide was obtained with a yield of 0.1 gm (52% of theory).

後処理

  1. temperaturethe reaction mixture was heated for two hours on a water bath
  2. customwas subsequently evaporated in vacuo to dryness
  3. dissolutionThe residue was dissolved in methylene chloride
  4. washthe solution was washed with water
  5. customAfter drying
  6. customevaporating of the organic phase

出典と根拠

ORDレコード
ord-d7329cedddb3408a8e1d2fb81ea7303b
出典データセット
uspto-grants-1980_11
特許番号
US04233299

反応ノート

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