Oxygen → ((4-Bromophenyl)ethynyl)triisopropylsilane

HRID 2246489

反応式

HRID 2246489 の反応式
[CH:1]([Si:4]([C:11]#[CH:12])([CH:8]([CH3:10])[CH3:9])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].C(N(CC)CC)C.O=O.[Br:22][C:23]1[CH:28]=[CH:27][C:26](I)=[CH:25][CH:24]=1>O1CCCC1.[Cu](I)I.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Br:22][C:23]1[CH:28]=[CH:27][C:26]([C:12]#[C:11][Si:4]([CH:5]([CH3:6])[CH3:7])([CH:1]([CH3:3])[CH3:2])[CH:8]([CH3:10])[CH3:9])=[CH:25][CH:24]=1

参加物

8

反応物 4

HCID 977OxygenHCID 8471TriethylamineHCID 115221-Bromo-4-iodobenzeneHCID 2734682(Triisopropylsilyl)acetylene

生成物 1

HCID 57809595((4-Bromophenyl)ethynyl)triisopropylsilane

試薬・触媒・溶媒 3

HCID 83717Copper iodide触媒HCID 178418476HCID 178418476、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

11.6 mL triisopropylsilylacetylen and 14.4 mL triethylamine followed by 0.2 g copper iodide and 0.73 g bis-(triphenylphosphine)-palladium dichloride are added under argon to an oxygen-free solution of 15.0 g 4-bromo-1-iodo-benzene in 150 mL dry tetrahydrofuran. The solution is stirred for 16 h at ambient temperature and then filtered through Celite and evaporated down. The residue is purified by chromatography on silica gel (cyclohexane).

後処理

  1. filtrationfiltered through Celite
  2. customevaporated down
  3. customThe residue is purified by chromatography on silica gel (cyclohexane)

出典と根拠

ORDレコード
ord-99738f654bff4a7da2cd2e1ca416f1a1
出典データセット
uspto-grants-2010_03
特許番号
US07687469B2

関連ノート

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