2-Bromobenzylamine hydrochloride → 2-Bromo-N-(tert-butoxycarbonyl)benzylamine

HRID 2247434ノート

反応式

HRID 2247434 の反応式
Cl.[Br:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH2:6].[C:11](OC([O-])=O)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>O1CCCC1>[Br:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH:6][C:11](=[O:12])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]

参加物

4

反応物 2

HCID 27242022-Bromobenzylamine hydrochlorideHCID 22064466Tert-butyldicarbonate

生成物 1

HCID 70183002-Bromo-N-(tert-butoxycarbonyl)benzylamine収率 82.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

15.0 g of 2-Bromobenzylamine hydrochloride was dissolved in 100 ml of tetrahydrofuran, and a solution of 13 g of t-butyl dicarbonate in tetrahydrofuran (25 ml) was added thereto. The mixture was stirred at room temperature for 1 hour, and then the solvent was evaporated. The residue was dissolved in ethyl acetate, and washed successively with 1N hydrochloric acid and brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated, to give 16.0 g of the title compound.

後処理

  1. customthe solvent was evaporated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed successively with 1N hydrochloric acid and brine
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-b11eb93fd399418695ca779846d3ebfa
出典データセット
uspto-grants-2010_03
特許番号
US07687664B2

反応ノート

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