Sodium Hydroxide → HCID 11978047、化合物

反応式

[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:28][N:29]2[CH2:32][CH:31]([C:33]([O:35]C)=[O:34])[CH2:30]2)[S:6][C:7]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[C:15]([F:27])[CH:14]=2)[O:10][N:9]=1)[CH3:2].[OH-].[Na+]>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:28][N:29]2[CH2:32][CH:31]([C:33]([OH:35])=[O:34])[CH2:30]2)[S:6][C:7]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[C:15]([F:27])[CH:14]=2)[O:10][N:9]=1)[CH3:2]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 68523928HCID 68523928、化合物

生成物 1

HCID 11978047HCID 11978047、化合物収率 83%

実験手順

The title compound (0.11 g) was synthesized in a yield of 83% as a white crystalline solid by conducting the reaction similar to that mentioned in Example 3 (3e) using methyl 1-[(4-ethyl-5-{5-[3-fluoro-4-(3-fluorophenoxy)phenyl]-1,2,4-oxadiazol-3-yl}-2-thienyl)methyl]azetidine-3-carboxylate (0.14 g, 0.27 mmol) that was obtained in Example 20 (20c) and a 1 N aqueous solution of sodium hydroxide (0.81 mL, 0.81 mmol).

後処理

customthe reaction similar to

出典と根拠

ORDレコード: ord-973af6e8fbec4819a37a6e615bebd57f
出典データセット: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07687491B2

反応ノート

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