Aniline → HCID 57125042、化合物

反応式

Cl[C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[NH2:9][C:10]1[CH:15]=[CH:14][CH:13]=C[CH:11]=1.[CH2:16]([O:18][C:19]([C:21]1[C:26](=[O:27])[N:25]2C(C)CCC[C:24]2=[N:23][CH:22]=1)=[O:20])[CH3:17].C(OC(C1C(=O)N2CC(C)CCC2=NC=1)=O)C>>[CH2:16]([O:18][C:19]([C:21]1[C:26](=[O:27])[N:25]2[CH2:24][CH:14]([CH3:13])[CH2:15][C:10](=[N:9][NH:6][C:5]3[CH:7]=[CH:8][CH:2]=[CH:3][CH:4]=3)[C:11]2=[N:23][CH:22]=1)=[O:20])[CH3:17]

参加物

反応物 4

HCID 6115Aniline

HCID 78124-Chloroaniline

HCID 208414Ethyl 6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylate

HCID 15570105Ethyl 7-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidine-3-carboxylate

生成物 1

HCID 57125042HCID 57125042、化合物収率 60.2%

実験手順

The process according to Example 6 is carried out except that p-chloro-aniline is replaced by aniline and ethyl-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidine-3-carboxylate is replaced by ethyl-7-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidine-3-carboxylate, respectively. Thus ethyl-9-(phenyl-hydrazono)-7-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidine-3-carboxylate is obtained with a yield of 60.2%. Mp.: 165°-167° C.