Benzoyl Peroxide → 2-(Bromomethyl)-5-chlorobenzo[d]oxazole

HRID 2247995

反応式

HRID 2247995 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH3:10])=[N:7][C:6]=2[CH:11]=1.[Br:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][Br:12])=[N:7][C:6]=2[CH:11]=1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 295105-Chloro-2-methylbenzoxazoleHCID 67184N-bromobutanimide

生成物 1

HCID 127459452-(Bromomethyl)-5-chlorobenzo[d]oxazole

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A solution of the benzoxazol (1.3 ) (Step 2) in CCl4 (15 mL) was treated with N-bromo-succinimide (NBS) (1.5 ) and benzoyl peroxide (38 mg) at reflux using a U.V. lamp for 24 hours. Filtration, evaporation, and flash chromatography of the residue using 1:1 hexane/toluene afforded the title compound which was used as such for the next step.

後処理

  1. temperatureat reflux
  2. filtrationFiltration, evaporation, and flash chromatography of the residue

出典と根拠

ORDレコード
ord-ff4e4791d10a445bbab656ba07c83a24
出典データセット
uspto-grants-1991_08
特許番号
US05037840

関連ノート

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