Trifluoroacetic acid → HCID 86744971、化合物

反応式

[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:18])[CH3:17])[NH:8]C(OC(C)(C)C)=O.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[CH3:1][O:2][C:3](=[O:20])[CH2:4][NH:5][C:6](=[O:19])[C@H:7]([CH:16]([CH3:17])[CH3:18])[NH2:8]

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 14235550N-[(1,1-Dimethylethoxy)carbonyl]-L-valylglycine methyl ester

生成物 1

HCID 86744971HCID 86744971、化合物

実験手順

t-butyloxycarbonyl-L-valyl-glycine methyl ester (1.44 g, 5 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was left at room temperature for 1 hour. The solution was evaporated to dryness in vacuo and the residue triturated with dry ether.

後処理

customThe solution was evaporated to dryness in vacuo
customthe residue triturated with dry ether

出典と根拠

ORDレコード: ord-79272b99fddf470bb0548622df5394de
出典データセット: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05037957

反応ノート

読み込み中…

参加物