Benzoyl Peroxide → HCID 19994737、化合物
反応式
[C:1]([C:3]1[O:4][C:5]2[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:6]=2[N:7]=1)#[N:2].[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[C:1]([C:3]1[O:4][C:5]2[CH:11]=[C:10]([CH2:12][Br:13])[CH:9]=[CH:8][C:6]=2[N:7]=1)#[N:2]参加物
5
実験手順
To a stirred solution of 2-cyano-6-methylbenzoxazole (2.0 g, 12.66 mmol) in carbon tetrachloride (50 ml) at room temperature are added successively N-bromosuccinimide (2.37 g, 13.3 mmol) and benzoyl peroxide (30.7 mg, 0.13 mmol). The solution is irradiated with a sun-lamp for 2 hours and concentrated. The residue is dissolved in 500 ml of ether and the solution filtered. The filtrate is concentrated and subjected to HPLC (2% ethyl acetate in hexane) to afford 2-cyano-6-bromomethylbenzoxazole which is used directly in the next step.
後処理
- customThe solution is irradiated with a sun-lamp for 2 hours
- concentrationconcentrated
- dissolutionThe residue is dissolved in 500 ml of ether
- filtrationthe solution filtered
- concentrationThe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-7cb29ee4d34f41269df4281a7ace959c
- 出典データセット
- uspto-grants-1991_08
- 特許番号
- US05041453
反応ノート
読み込み中…