1-Propanol → n-Propyl-5-hydroxybenzoxazole-2-carboxylate

HRID 2248882ノート

反応式

HRID 2248882 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:7]=2[N:8]=1)([OH:3])=[O:2].[CH2:14](O)[CH2:15][CH3:16]>S(=O)(=O)(O)O>[CH2:14]([O:2][C:1]([C:4]1[O:5][C:6]2[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][C:7]=2[N:8]=1)=[O:3])[CH2:15][CH3:16]

参加物

4

反応物 2

HCID 10311-PropanolHCID 199946752-Carboxy-5-hydroxybenzoxazole

生成物 1

HCID 86745010n-Propyl-5-hydroxybenzoxazole-2-carboxylate

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid触媒

実験手順

12.72 g (49.2 mmoles) of 2-carboxy-5-hydroxybenzoxazole is dissolved in 200 ml of n-propanol and 1 drop of concentrated sulfuric acid is added. The mixture is refluxed for 30 hours, concentrated. The resulting solid is suspended in water, neutralized with sodium bicarbonate and filtered, washing the solid with water, then drying. This gives n-propyl-5-hydroxybenzoxazole-2carboxylate which is purified by recrystallization from n-propanol/acetone or by HPLC.

後処理

  1. temperatureThe mixture is refluxed for 30 hours
  2. concentrationconcentrated
  3. filtrationfiltered
  4. washwashing the solid with water
  5. customdrying
  6. customThis gives n-propyl-5-hydroxybenzoxazole-2carboxylate which is purified by recrystallization from n-propanol/acetone or by HPLC

出典と根拠

ORDレコード
ord-d0d085ee63aa4284af57944cf079e191
出典データセット
uspto-grants-1991_08
特許番号
US05041453

反応ノート

読み込み中…