Hydrochloric Acid → 1-[[2-(5-Methoxy-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol hydrochloride

HRID 224893

反応式

HRID 224893 の反応式
[CH3:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH:6]1[CH2:8][O:7]1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH:19]=[C:18]2[CH2:24][C:25]([CH3:28])([CH3:27])[NH2:26].[ClH:29]>C(#N)C>[ClH:29].[CH3:13][O:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][CH:19]=[C:18]2[CH2:24][C:25]([NH:26][CH2:8][CH:6]([OH:7])[CH2:5][O:4][C:3]1[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=1[CH3:1])([CH3:27])[CH3:28]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 16640o-CRESYL GLYCIDYL ETHERHCID 126196645-METHOXY-alpha,alpha-DIMETHYL-1H-INDOL-3-YL-ETHANEAMINE

生成物 1

HCID 126196551-[[2-(5-Methoxy-3-indolyl)-1,1-dimethylethyl]amino]-3-(2-methylphenoxy)-2-propanol hydrochloride

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

(2-Methylphenoxymethyl)oxirane, 4.1 g., (0.025 mole) and 5.4 g. (0.025 mole) of 5-methoxy-α,α-dimethyl-1H-indol-3-yl-ethaneamine were mixed and heated at 130° for 2 hrs. The mixture was allowed to cool, but while still warm was dissolved in 60 ml. of acetonitrile and acidified with ethanolic 5 N HCl to pH 2. Th product crystallized as the hydrochloride salt, yield 8.3 g.; recrystallized from isopropanol/methanol, yield 7.4 g., m.p. 201.0°-203.0°.

後処理

  1. temperatureheated at 130° for 2 hrs
  2. temperatureto cool
  3. temperaturewhile still warm
  4. dissolutionwas dissolved in 60 ml
  5. customTh product crystallized as the hydrochloride salt, yield 8.3 g
  6. customrecrystallized from isopropanol/methanol, yield 7.4 g

出典と根拠

ORDレコード
ord-61aa6cb77161491289fcaab900c15c69
出典データセット
uspto-grants-1980_11
特許番号
US04234595

関連ノート

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