Tributylstannane → S(-)-1-(PENTAFLUOROPHENYL)ETHANOL

HRID 2249008ノート

反応式

HRID 2249008 の反応式
Cl[CH2:2][C@@H:3]([C:5]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:7]([F:14])[C:6]=1[F:15])[OH:4].C([SnH](CCCC)CCCC)CCC.CC(N=NC(C#N)(C)C)(C#N)C>>[F:11][C:10]1[C:5]([C@@H:3]([OH:4])[CH3:2])=[C:6]([F:15])[C:7]([F:14])=[C:8]([F:13])[C:9]=1[F:12]

参加物

4

反応物 3

HCID 5948TributylstannaneHCID 6547AzobisisobutyronitrileHCID 54517612HCID 54517612、化合物

生成物 1

HCID 6993305S(-)-1-(PENTAFLUOROPHENYL)ETHANOL収率 66.2%

反応条件

温度
80 °C

実験手順

A mixture of 1.23 g of (R)-(-)-2-chloro-1-(pentafluorophenyl)ethanol obtained in Example 8, 1.60 ml of tributyltin hydride, and 16 mg of AIBN was stirred for eight hours at 80° C. After completion of reaction, the reaction mixture was purified by silica gel column chromatography to give 0.7 g of (S)-(-)-1-(pentafluorophenyl)-ethanol.

後処理

  1. customAfter completion of reaction
  2. customthe reaction mixture was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-f6c1ed12612047a2aac580c204f1042d
出典データセット
uspto-grants-1991_08
特許番号
US05041641

反応ノート

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