Methanol → HCID 86737342、化合物
反応式
[CH3:1][O:2][C:3](=[O:11])[CH:4](Br)[CH2:5][CH2:6][CH2:7][CH2:8][Cl:9].[O-:12][C:13]#[N:14].[K+].[CH3:16][OH:17]>C(#N)C.[O-]C#N.CN(C)C(=[N+](C)C)N(C)C>[CH3:1][O:2][C:3](=[O:11])[C:4]([N:14]=[C:13]=[O:12])([O:17][CH3:16])[CH2:5][CH2:6][CH2:7][CH2:8][Cl:9]参加物
6
実験手順
12.78 grams of 2-bromo-6-chlorohexanoic acid methyl ester, 6.08 grams of potassium cyanate, 3.50 grams of methanol and 0.25 gram of hexamethyl guanidinium cyanate were heated in 70 ml of acetonitrile for 25 hours at 80° C. under strong stirring. The reaction mixture was worked up as described in Example 1. There were obtained 7.59 grams (60.7%) of 6-chloro-2-methoxy-carbonylaminohexanoic acid methyl ester which was saponified as in Example 14 to 2-amino-6-chlorohexanoic acid hydrochloride.
出典と根拠
- ORDレコード
- ord-d54364e2857c456c9a5a5c0aafc2443c
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04234744
反応ノート
読み込み中…