Sodium Hydroxide → 4,4-Dimethylpentanoic acid

HRID 2249957

反応式

HRID 2249957 の反応式
C[O:2][C:3](=[O:10])[CH2:4][CH2:5][C:6]([CH3:9])([CH3:8])[CH3:7].[OH-].[Na+]>O.C(Cl)Cl>[CH3:7][C:6]([CH3:9])([CH3:8])[CH2:5][CH2:4][C:3]([OH:10])=[O:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 126561444,4-Dimethyl-pentanoic acid methyl ester

生成物 1

HCID 142374,4-Dimethylpentanoic acid収率 85%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

4,4-Dimethyl-pentanoic acid methyl ester (7.0 g, 48.5 mmol, 1.0 eq.) was treated with a solution of NaOH (4.0 g, 100 mmol, 2.1 eq.) in water (5 mL). The homogeneous solution was allowed to stir for 4-5 hours. The reaction was diluted with CH2Cl2 and the aqueous layer was extracted with CH2Cl2 (50 mL×3). The aqueous layer was acidified with 6M HCl to pH ˜1.5 and extracted with ethyl acetate (50 mL×3). The combined ethyl acetate fractions were dried over MgSO4, filtered and evaporated to provide 4,4-dimethyl-pentanoic acid (5.35 g, 41.1 mmol, 85%) as a colorless oil: 1H NMR (CDCl3, 400 MHz) δ 0.89 (s, 9H), 1.53-1.57 (m, 2H), 2.26-2.30 (m, 2H).

後処理

  1. extractionthe aqueous layer was extracted with CH2Cl2 (50 mL×3)
  2. extractionextracted with ethyl acetate (50 mL×3)
  3. dry with materialThe combined ethyl acetate fractions were dried over MgSO4
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-5b687da4582f466caea59f2af1c54346
出典データセット
uspto-grants-2008_01
特許番号
US07314872B2

関連ノート

読み込み中…