2(1h)-Quinazolinone,3,4-dihydro-8-methoxy-3-[1-(phenylmethyl)-4-piperidinyl]- → 8-Methoxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one

HRID 2250257ノート

反応式

HRID 2250257 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][C:22]3[C:17](=[C:18]([O:24][CH3:25])[CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]2=[O:26])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH3:25][O:24][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:17]=1[NH:16][C:15](=[O:26])[N:14]([CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH2:23]2

参加物

4

反応物 1

HCID 211021562(1h)-Quinazolinone,3,4-dihydro-8-methoxy-3-[1-(phenylmethyl)-4-piperidinyl]-

生成物 1

HCID 183210478-Methoxy-3-piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one収率 93%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3-(1-Benzyl-piperidin-4-yl)-8-methoxy-3,4-dihydro-1H-quinazolin-2-one (100 mg, 0.28 mmol) in methanol (5 mL) was flushed with nitrogen, and treated with palladium on charcoal (10%, 10 mg). The flask was flushed with hydrogen and allowed to stir under an atmosphere of hydrogen overnight. The reaction was flushed with nitrogen, filtered through celite, and concentrated. Column chromatography gave 68 mg (93%) of the desired material. LC/MS: tR=1.11 min, 262.23 (MH)+.

後処理

  1. customThe flask was flushed with hydrogen
  2. customThe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-1b4a5ad1d8ea44599dc06ff86c11de49
出典データセット
uspto-grants-2008_01
特許番号
US07314883B2

反応ノート

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