Isobutyraldehyde → Benzyl(2-methylpropyl)amine
反応式
[CH:1](=O)[CH:2]([CH3:4])[CH3:3].[CH2:6]([NH2:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.P(O)(O)O>O>[CH2:6]([NH:13][CH2:1][CH:2]([CH3:4])[CH3:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
5
実験手順
To the imine from isobutyraldehyde and benzylamine (51.4 g; 0.3 mole) was added phosphorous acid (24.6 g; 0.3 mole). While stirring the mixture was slowly warmed to 65°-70° when a vigorous exothermic reaction was initiated. The reaction temperature reached 130°-145°. Upon cooling the reaction mixture became a glass. This glass was dissolved in water and basified. Extraction with benzene yielded benzylisobutylamine. The aqueous portion was acidified and after removal of sodium chloride yielded a phosphonic acid (20 g). Recrystallization gave a white solid (12 g) mp 186°-190° the N-benzyl α-aminophosphonic acid. ##STR35##
後処理
- temperaturewas slowly warmed to 65°-70° when
- customa vigorous exothermic reaction
- customreached 130°-145°
- temperatureUpon cooling the reaction mixture
- extractionExtraction with benzene
出典と根拠
- ORDレコード
- ord-c4b49112a199428c8473cdf55ff1b8ff
- 出典データセット
- uspto-grants-1980_11
- 特許番号
- US04235809
反応ノート
読み込み中…